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PhysioVerse MPS Engine
PhysioVerse MPS Engine
Map DOI-level organoid, organ-on-chip, and microphysiological systems data records by model system, tissue, assay, data modality, validation, regulatory, and related scientific features.
PhysioVerse MPS Engine
Map MPS data by model system, tissue, assay, data modality, and validation features
The PhysioVerse MPS Engine helps users explore organoid, organ-on-chip, and microphysiological systems data records. It connects each record to mapped features such as model system, organ or tissue, disease area, species, cell source, biomaterial, assay, omics modality, sensor technology, validation language, and regulatory terminology. Users can search by DOI, data ID, year, record type, contact information, or mapped scientific features.
How to use this toolUse the search bar to find a DOI, year, contact email, record type, or scientific term. Use the feature filters to narrow results by model system, organ or tissue, disease area, data modality, assay, biomaterial, validation, regulatory language, and related categories.
How this differs from the PhysioVerse Data FinderThe PhysioVerse Data Finder focuses on curated study-level records with titles and main-variable filters. The PhysioVerse MPS Engine is a broader DOI-level data map that connects records to many scientific feature groups and data modalities.
6,923Total records
6,923Matching records
29Feature groups
0Active filters
Data feature network
How matching data records cluster by shared features
Each node is one data record. Edges connect records that share model-system, tissue, assay, data-modality, validation, regulatory, or related scientific features. Select a node to review the data record and its five closest matching records.
Top model systems
Top organs / tissues
Top disease / toxicity areas
Filtered data
6,923 matching data records
| DOI | Year | Type | Contact | Matched feature groups |
|---|---|---|---|---|
| 10.1093/procel/pwag001P00015 | 2026 | Original | — | Study characteristics: Organoid | Model systems: Organoid | Organs / tissues: Skin | Regulatory: ICH | Supplements: ITS |
| 10.1101/cshperspect.a041736P00030 | 2026 | Original | cabateshen@columbia.edu | Study characteristics: Organoid, Omics, Regulatory Language, Patient-derived | Quantitative reporting: Concentration | Model systems: Organoid | Organs / tissues: Brain, Eye, Lung, Alveolar, Liver, Intestine / intestinal, Colon | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Lung Cancer, Pancreatic Cancer, Prostate Cancer | Cell sources: ESC, Patient-derived, Stem cell, Cell line, Cell lines, Crispr, Genetically Engineered | Cell types: Epithelial cell, Immune cell, T cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.1146/annurev-bioeng-122019-P00032 | 2026 | Evidence synthesis | Charles.gersbach@duke.edu | Study characteristics: Organoid, Drug Testing, Biomaterials, Omics, Ai, Regulatory Language, Patient-derived | Quantitative reporting: Time / exposure duration, Shear stress | Model systems: Organoid, Spheroid | Organs / tissues: Brain, Cerebral, Neural, Retina, Eye, Lung, Liver | Diseases / toxicity: Alzheimer, ALS, Glioblastoma, Cancer, Tumor, Breast Cancer, Lung Cancer | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Primary cell, Primary cells, Patient-derived, Stem cell | Cell types: Endothelial cell, Fibroblast, Epithelial cell, Neuron, Intestinal Stem Cell, Beta cell, Immune cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.3390/jof12030214P00034 | 2026 | Evidence synthesis | nawal.abdul-baki@my.utsa.edu | Study characteristics: Organoid, Drug Testing, Sensors, Ai, Regulatory Language, Validation | Quantitative reporting: Sample size / replicates | Model systems: Organoid, MPS | Organs / tissues: Eye, Lung, Alveolar, Liver, Kidney, Colon, Bone | Diseases / toxicity: ALS, Cancer, Tumor, COVID-19, Infection, Diabetes, Toxicity | Cell sources: ESC, Genetically Engineered, Fibroblast, Epithelial cell | Cell types: Fibroblast, Epithelial cell, Oligodendrocyte, Immune cell, T cell, B cell, Macrophage | Species: Human, Mouse, Rat, Pig, Dog, Non Human Primate, Monkey |
| 10.1038/s44385-026-00067-9P00042 | 2026 | Evidence synthesis | sylvia.boj@merckgroup.com | Study characteristics: Organoid, Drug Testing, Biomaterials, Omics, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid | Organs / tissues: Intestine / intestinal, Colon, Breast, Tumor | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Pancreatic Cancer, Toxicity | Cell sources: ESC, Patient-derived, Adult stem cell, Stem cell, Stem cells, Cell line, Cell lines | Cell types: Epithelial cell | Species: Human, Rat |
| 10.1128/jvi.02219-20.P00044 | 2026 | Original | daiutol@upmc.edu | Study characteristics: Organoid, Biomaterials, Sensors, Omics, Regulatory Language, iPSC | Quantitative reporting: Concentration, Time / exposure duration | Model systems: Organoid | Organs / tissues: Brain, Cerebral, Neural, Skin | Diseases / toxicity: Alzheimer, ALS, Infection | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Stem cell, Stem cells, Cell line, Cell lines | Cell types: Neuron | Species: Human, Mouse, Rat, Dog |
| 10.3389/fmed.2025.1733668P00049 | 2026 | Review | acara@metu.edu.tr | Study characteristics: Organoid, Microfluidics, Drug Testing, Biomaterials, Sensors, Omics, Ai | Quantitative reporting: Time / exposure duration | Model systems: Organoid, Spheroid, Assembloid, MPS | Organs / tissues: Neural, Retina, Airway, Liver, Gut, Intestine / intestinal, Colon | Diseases / toxicity: ALS, Glioblastoma, Cancer, Tumor, Breast Cancer, Pancreatic Cancer, Prostate Cancer | Cell sources: iPSC, ESC, Patient-derived, Stem cell, Stem cells, Cell line, Cell lines | Cell types: Hepatocyte, Endothelial cell, Fibroblast, Epithelial cell, Enterocyte, Immune cell, T cell | Species: Human, Mouse, Rat, Pig |
| 10.1128/mbio.01316-24P00062 | 2026 | Review | ramani@bcm.edu | Study characteristics: Organoid, Organ-on-chip, Biomaterials, Sensors, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration | Model systems: Organoid, Organ-on-chip, MPS | Organs / tissues: Eye, Liver, Kidney, Gut, Intestine, Intestine / intestinal, Colon | Diseases / toxicity: ALS, Cancer, Tumor, Leukemia, Infection, Diabetes, Inflammatory bowel disease | Cell sources: ESC, Stem cell, Stem cells, Immortalized, Cell line, Cell lines, Epithelial cell | Cell types: Epithelial cell, Intestinal Stem Cell, Enterocyte, Goblet Cell, Paneth Cell, Tuft Cell, Immune cell | Species: Human, Mouse, Rat, Pig |
| 10.1371/journal.pbio.3003597P00073 | 2026 | Review | jochen.wittbrodt@cos.uni-heidelberg.de | Study characteristics: Organoid, Biomaterials, Omics, Ai, Regulatory Language, Validation, iPSC | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid | Organs / tissues: Neural, Retina, Eye, Liver, Kidney, Gut, Intestine / intestinal | Diseases / toxicity: Alzheimer, ALS, Cancer | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Stem cell, Stem cells | Cell types: T cell | Species: Human, Mouse, Rat, Zebrafish, Pig |
| 10.1039/d5lc01062dP00093 | 2026 | Review | karan.ahuja@kuleuven.be | Study characteristics: Organoid, Microfluidics, Drug Testing, Biomaterials, Sensors, Omics, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Spheroid | Organs / tissues: Brain, Cerebral, Neural, Liver, Immune | Diseases / toxicity: Alzheimer, ALS | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Stem cell, Stem cells, Immortalized | Cell types: Microglia, Oligodendrocyte, Neuron, T cell | Species: Human, Mouse, Rat |
| 10.1261/rnaP00096 | 2026 | Review | rajewsky@mdc-berlin.de | Study characteristics: Organoid, Microfluidics, Omics, Ai, Regulatory Language, Validation, Primary cells | Quantitative reporting: Concentration | Model systems: Organoid, MPS | Organs / tissues: Brain, Cerebral, Neural, Retina, Lung, Gut, Breast | Diseases / toxicity: Alzheimer, Parkinson, Huntington, ALS, Cancer, Tumor, Breast Cancer | Cell sources: ESC, Primary cell, Primary cells, Stem cell, Cell line, Cell lines, Crispr | Cell types: Fibroblast, Neuron, Dopaminergic Neuron, Motor Neuron, T cell | Species: Human, Mouse, Rat, Zebrafish, Dog |
| 10.3389/fnmol.2026.1671909P00147 | 2026 | Evidence synthesis | z.ahmed.1@bham.ac.uk | Study characteristics: Organoid, Biomaterials, Omics, Ai, Regulatory Language, Patient-derived, iPSC | Model systems: Organoid | Organs / tissues: Brain, Cerebral, Neural, Muscle, Immune | Diseases / toxicity: Alzheimer, ALS, Cancer, Infection | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Patient-derived, Stem cell, Stem cells, Immortalized | Cell types: Fibroblast, Neuron, Motor Neuron, T cell | Species: Human, Mouse, Rat, Dog | Drugs / perturbagens: 5-fluorouracil, Fluorouracil, Etoposide |
| 10.1101/gr.280338.124P00171 | 2026 | Review | ysju@kaist.ac.kr | Study characteristics: Organoid, Drug Testing, Biomaterials, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, MPS | Organs / tissues: Brain, Lung, Gut, Intestine, Intestine / intestinal, Bone, Breast | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Lung Cancer, Sars Cov, Infection | Cell sources: ESC, Stem cell, Stem cells, Cell line, Cell lines, Crispr, Fibroblast | Cell types: Endothelial cell, Fibroblast, Epithelial cell, T cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.14336/ad.2024.10016P00172 | 2026 | Review | jingy4172@shu.edu.cn | Study characteristics: Organoid, Biomaterials, Omics, Regulatory Language, Validation, iPSC | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid | Organs / tissues: Liver, Bone, Cartilage, Muscle, Placenta, Bone Marrow | Diseases / toxicity: ALS, Cancer, Toxicity | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Stem cell, Stem cells, Mesenchymal stem cell, MSC | Cell types: T cell | Species: Human, Mouse, Rat |
| 10.64898/2026.03.29.715116;P00175 | 2026 | Evidence synthesis | prghosh@ucsd.edu | Study characteristics: Organoid, Biomaterials, Sensors, Omics, Ai, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density, Pore size | Model systems: Organoid, MPS | Organs / tissues: Brain, Lung, Heart, Liver, Gut, Intestine, Intestine / intestinal | Diseases / toxicity: ALS, Cancer, Tumor, Infection, Fibrosis, NASH, Inflammatory bowel disease | Cell sources: ESC, Patient-derived, Stem cell, Stem cells, Cell line, Cell lines, Crispr | Cell types: Epithelial cell, Intestinal Stem Cell, Immune cell, T cell, Macrophage | Species: Human, Mouse, Rat, Pig, Dog |
| 10.3390/molecules31101622P00178 | 2026 | Evidence synthesis | julia_anchimowicz@sggw.edu.pl | Study characteristics: Organoid, Organ-on-chip, MPS, Microfluidics, Drug Testing, Biomaterials, Sensors | Model systems: Organoid, Spheroid, Organ-on-chip, Microphysiological systems, MPS | Organs / tissues: Brain, Cerebral, Neural, Retina, Eye, Lung, Liver | Diseases / toxicity: Alzheimer, Parkinson, ALS, Tumor, Toxicity | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Stem cell, Stem cells, Epithelial cell, Endothelial cell | Cell types: Endothelial cell, Pericyte, Epithelial cell, Astrocyte, Microglia, Neuron, Dopaminergic Neuron | Species: Human, Rat, Zebrafish | Drugs / perturbagens: TNF-alpha |
| 10.1128/msystems.00161-19.P00204 | 2026 | Original | silvarochar@gmail.com | Study characteristics: Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration | Diseases / toxicity: ALS | Cell sources: ESC | Cell types: T cell | Species: Rat, Dog | Chip materials: Glass | Media: MEM |
| 10.1101/gr.280355.124P00214 | 2026 | Review | — | Study characteristics: Sensors, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Organs / tissues: Neural, Retina, Eye, Alveolar, Heart, Liver, Kidney | Diseases / toxicity: ALS, Cancer | Cell sources: ESC, Stem cell, Cell line | Cell types: Neuron, T cell, B cell, Macrophage | Species: Human, Mouse, Rat, Zebrafish, Pig, Dog | Chip materials: Glass |
| 10.1101/gr.127712.111P00245 | 2026 | Original | cleslie@cbio.mskcc.org | Study characteristics: Omics, Regulatory Language | Organs / tissues: Immune | Diseases / toxicity: ALS, Cancer | Cell sources: ESC, Embryonic Stem Cell, Stem cell, Stem cells, Immortalized, Cell line, Cell lines | Cell types: T cell, B cell, Macrophage | Species: Human, Mouse, Rat | Chip materials: COC, Glass | Media: MEM |
| 10.22074/cellj.2026.2069129.1910P00254 | 2026 | Evidence synthesis | Barabadiz@medsab.ac.ir | Study characteristics: Organoid, Microfluidics, Drug Testing, Biomaterials, Regulatory Language, Validation, iPSC | Quantitative reporting: Concentration, Time / exposure duration | Model systems: Organoid, Spheroid | Organs / tissues: Eye, Liver, Liver / hepatic, Kidney, Skin, Bone, Tumor | Diseases / toxicity: ALS, Tumor, Fibrosis, Toxicity, Hepatotoxicity | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Adult stem cell, Stem cell, Stem cells | Cell types: Hepatocyte, Cholangiocyte, Endothelial cell, Fibroblast, T cell, Macrophage | Species: Human, Mouse, Rat, Pig |
| 10.1128/mbio.00662-15.P00262 | 2026 | Original | j.w.veening@rug.nl | Study characteristics: Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Organs / tissues: Eye, Heart, Colon | Diseases / toxicity: ALS | Cell sources: ESC | Cell types: T cell | Species: Human, Rat | Biomaterials / ECM: Agarose |
| 10.1101/gr.168930.113P00263 | 2026 | Original | lapennacchio@lbl.gov | Study characteristics: Omics, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: MPS | Organs / tissues: Brain, Neural, Eye, Heart, Cardiac, Gut, Colon | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer | Cell sources: ESC, Embryonic Stem Cell, Stem cell, Stem cells, Cell line, Cell lines | Cell types: Oligodendrocyte, Neuron, T cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.3389/fimmu.2026.1736584P00265 | 2026 | Review | elisabeth.husar@roche.com | Study characteristics: Organoid, MPS, Drug Testing, Biomaterials, Sensors, Ai, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid, Spheroid, Microphysiological systems, MPS | Organs / tissues: Brain, Lung, Airway, Alveolar, Heart, Liver, Kidney | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Lung Cancer, Infection, Toxicity | Cell sources: iPSC, ESC, Embryonic Stem Cell, Primary cell, Primary cells, Patient-derived, Stem cell | Cell types: Hepatocyte, Cardiomyocyte, Endothelial cell, Vascular endothelial cell, Epithelial cell, Astrocyte, Neuron | Species: Human, Mouse, Rat, Monkey |
| 10.3390/cells15060544P00277 | 2026 | Review | chaima.ayachi@univ-cotedazur.fr | Study characteristics: Organoid, Biomaterials, Omics, Regulatory Language, Validation, Primary cells | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, MPS | Organs / tissues: Gut, Intestine, Intestine / intestinal, Colon, Pancreas, Islet, Tumor | Diseases / toxicity: ALS, Cancer, Tumor, Diabetes | Cell sources: ESC, Embryonic Stem Cell, Primary cell, Stem cell, Stem cells, Cell line, Crispr | Cell types: Epithelial cell, Intestinal Stem Cell, Beta cell, T cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.3389/fcell.2025.1750142P00292 | 2026 | Review | Tahani.baakdhah@mail.utoronto.ca | Study characteristics: Organoid, Microfluidics, Drug Testing, Biomaterials, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Assembloid | Organs / tissues: Brain, Neural, Retina, Eye, Gut, Bone, Vascular | Diseases / toxicity: ALS, Toxicity | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Patient-derived, Adult stem cell, Stem cell | Cell types: Fibroblast, Astrocyte, Microglia, Neuron, Alpha cell, T cell | Species: Human, Mouse, Rat, Pig, Dog, Non Human Primate, Monkey |
| 10.1038/s41419-026-08476-9P00308 | 2026 | Original | lippo3364@gmail.com | Study characteristics: Organoid, Biomaterials, Omics, Regulatory Language, Patient-derived, iPSC | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid | Organs / tissues: Brain, Cerebral, Neural, Liver, Skin, Muscle, Tumor | Diseases / toxicity: Alzheimer, Parkinson, ALS, Tumor, Toxicity | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Patient-derived, Stem cell, Stem cells | Cell types: Epithelial cell, Neuron, Motor Neuron, T cell, B cell | Species: Human, Mouse, Rat |
| 10.3389/fncel.2026.1776439P00328 | 2026 | Evidence synthesis | abak@ukaachen.de | Study characteristics: Organoid, MPS, Microfluidics, Drug Testing, Biomaterials, Sensors, Omics | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Spheroid, Assembloid, Microphysiological systems, MPS | Organs / tissues: Brain, Cerebral, Neural, Retina, Eye, Heart, Liver | Diseases / toxicity: Alzheimer, Parkinson, Huntington, ALS, Glioblastoma, Cancer, Tumor | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Primary cell, Primary cells, Patient-derived | Cell types: Endothelial cell, Pericyte, Epithelial cell, Astrocyte, Microglia, Oligodendrocyte, Neuron | Species: Human, Mouse, Rat, Pig, Dog, Non Human Primate, Chimpanzee |
| 10.1128/mbioP00337 | 2026 | Review | vastone@ucsc.edu | Study characteristics: Sensors, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration | Model systems: MPS | Organs / tissues: Eye, Liver, Gut, Intestine, Intestine / intestinal, Colon, Immune | Diseases / toxicity: ALS, Infection, Toxicity | Cell sources: ESC, Epithelial cell | Cell types: Epithelial cell, T cell, Macrophage | Species: Human, Mouse, Rat, Dog |
| 10.3390/medicina62030554P00344 | 2026 | Evidence synthesis | balmus.ioanamiruna@yahoo.com | Study characteristics: Organoid, Organ-on-chip, Microfluidics, Drug Testing, Biomaterials, Sensors, Ai | Quantitative reporting: Time / exposure duration, Sample size / replicates | Model systems: Organoid, Organ-on-chip, MPS | Organs / tissues: Brain, Neural, Kidney, Gut, Intestine, Intestine / intestinal, Colon | Diseases / toxicity: ALS, Cancer, Tumor, Infection, Inflammatory bowel disease, IBD, Crohn disease | Cell sources: ESC, Primary cell, Primary cells, Patient-derived, Stem cell, Stem cells, Cell line | Cell types: Epithelial cell, Neuron, Enterocyte, Goblet Cell, Immune cell, T cell, Macrophage | Species: Human, Mouse, Rat, Pig, Dog |
| 10.1128/mmbr.68.2.345-361.2004.P00375 | 2026 | Evidence synthesis | Cheryl.Nickerson@asu.edu | Study characteristics: Organoid, Organ-on-chip, Microfluidics, Drug Testing, Biomaterials, Sensors, Omics | Quantitative reporting: Concentration | Model systems: Organoid, Organ-on-chip, MPS | Organs / tissues: Brain, Cerebral, Neural, Retina, Eye, Lung, Airway | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Infection, NASH, Toxicity | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Primary cell, Primary cells, Patient-derived | Cell types: Hepatocyte, Cardiomyocyte, Endothelial cell, Pericyte, Epithelial cell, Astrocyte, Neuron | Species: Human, Mouse, Rat, Pig, Dog |
| 10.1128/spectrum.04397-22P00377 | 2026 | Review | mvandyk2@kennesaw.edu | Study characteristics: Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: MPS | Organs / tissues: Eye, Bone | Diseases / toxicity: ALS | Cell sources: ESC | Species: Rat | Media: MEM |
| 10.3389/fcell.2025.1693923P00382 | 2026 | Evidence synthesis | abashi@msm.edu | Study characteristics: Organoid, Organ-on-chip, MPS, Microfluidics, Drug Testing, Biomaterials, Omics | Quantitative reporting: Time / exposure duration, Sample size / replicates | Model systems: Organoid, Spheroid, Organ-on-chip, Microphysiological systems, MPS | Organs / tissues: Brain, Neural, Eye, Lung, Liver, Kidney, Placenta | Diseases / toxicity: ALS, Cancer, Tumor, Infection, Diabetes, Toxicity | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Primary cell, Patient-derived, Stem cell | Cell types: Neuron, Immune cell, T cell | Species: Human, Mouse, Rat, Pig, Non Human Primate |
| 10.1038/s42003-026-09570-6P00386 | 2026 | Review | r.lindeboom@nki.nl | Study characteristics: Organoid, Biomaterials, Omics, Ai, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Flow rate | Model systems: Organoid | Organs / tissues: Neural, Lung, Kidney / renal, Colon, Bone, Testis, Tumor | Diseases / toxicity: ALS, Cancer, Tumor, Lung Cancer, Pancreatic Cancer | Cell sources: ESC, Patient-derived, Immortalized, Cell line, Cell lines, Crispr | Cell types: Immune cell, T cell | Species: Human, Mouse, Rat |
| 10.1371/journal.ppat.1013867P00394 | 2026 | Review | supattapone@dartmouth.edu | Study characteristics: Organoid, Drug Testing, Biomaterials, Omics, Regulatory Language, Validation, iPSC | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid, MPS | Organs / tissues: Brain, Cerebral, Neural, Liver, Kidney, Intestine, Colon | Diseases / toxicity: Parkinson, ALS, Tumor, Infection, Toxicity, Neurotoxicity | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Stem cell, Stem cells, Cell line, Cell lines | Cell types: Astrocyte, Neuron, T cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.1128/mbio.01947-15.P00395 | 2026 | Original | pjkiley@wisc.edu | Study characteristics: Omics, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Oxygen concentration | Organs / tissues: Eye, Lung, Liver, Colon | Diseases / toxicity: ALS, Cancer | Cell sources: ESC | Cell types: T cell | Species: Rat, Dog | Chip materials: COC |
| 10.1152/ajpgi.00193.2025P00397 | 2026 | Original | martin.beaumont@inrae.fr | Study characteristics: Organoid, Drug Testing, Biomaterials, Sensors, Omics, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration | Model systems: Organoid | Organs / tissues: Neural, Eye, Liver, Liver / hepatic, Gut, Intestine, Intestine / intestinal | Diseases / toxicity: ALS | Cell sources: ESC, Stem cell, Stem cells, Cell line, Cell lines, Epithelial cell | Cell types: Epithelial cell, Goblet Cell, Paneth Cell, Immune cell, T cell, B cell, Macrophage | Species: Human, Mouse, Rat, Pig |
| 10.1007/s00604-026-08062-yP00420 | 2026 | Evidence synthesis | antonio.moreda@usc.es | Study characteristics: Organoid, Organ-on-chip, Microfluidics, Sensors, Omics, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Organ-on-chip | Organs / tissues: Gut, Intestine, Intestine / intestinal, Skin, Immune | Diseases / toxicity: ALS, Toxicity | Cell sources: ESC, Epithelial cell | Cell types: Epithelial cell, T cell | Species: Human, Rat, Pig |
| 10.1016/j.ebiom.2026.106201.P00426 | 2026 | Original | l.bauer@erasmusmc.nl | Study characteristics: Organoid, Organ-on-chip, Biomaterials, Omics, Regulatory Language, Validation, iPSC | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Assembloid, Organ-on-chip | Organs / tissues: Brain, Cerebral, Neural, Eye, Airway, Intestine / intestinal, Bone | Diseases / toxicity: ALS, Leukemia, COVID-19, Sars Cov, Infection, Toxicity, Neurotoxicity | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Stem cell, Stem cells, Cell line, Fibroblast | Cell types: Endothelial cell, Vascular endothelial cell, Fibroblast, Astrocyte, Microglia, Neuron, Motor Neuron | Species: Human, Mouse, Rat, Pig |
| 10.1021/acs.molpharmaceut.5c01122P00435 | 2026 | Evidence synthesis | — | Study characteristics: Organoid, Organ-on-chip, MPS, Microfluidics, Drug Testing, Biomaterials, Sensors | Quantitative reporting: Concentration, Time / exposure duration, Flow rate, Shear stress | Model systems: Organoid, Spheroid, Organ-on-chip, Organ Chip, Microphysiological systems, MPS, Multi-organ chip | Organs / tissues: Brain, Neural, Eye, Lung, Heart, Cardiac, Liver | Diseases / toxicity: Alzheimer, Parkinson, ALS, Cancer, Tumor, COVID-19, Infection | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Primary cell, Primary cells, Patient-derived, Stem cell | Cell types: Hepatocyte, Cholangiocyte, Cardiomyocyte, Endothelial cell, Fibroblast, Epithelial cell, Neuron | Species: Human, Mouse, Rat, Pig, Dog |
| 10.64898/2026.01.10.698817;P00444 | 2026 | Review | ken.cadwell@pennmedicine.upenn.edu | Study characteristics: Organoid, Sensors, Regulatory Language, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, MPS | Organs / tissues: Liver, Gut, Intestine, Intestine / intestinal, Colon, Bone, Immune | Diseases / toxicity: ALS, Cancer, COVID-19, Sars Cov, Infection, Inflammatory bowel disease, IBD | Cell sources: ESC, Patient-derived, Stem cell, Stem cells, Genetically Engineered, Epithelial cell | Cell types: Epithelial cell, Intestinal Stem Cell, Enterocyte, Goblet Cell, Paneth Cell, Tuft Cell, Immune cell | Species: Human, Mouse, Rat |
| 10.1016/j.bbalip.2026.159719P00456 | 2026 | Evidence synthesis | giulio.muccioli@uclouvain.be | Study characteristics: Organoid, Biomaterials, Sensors, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, TEER value | Model systems: Organoid, Spheroid | Organs / tissues: Brain, Eye, Lung, Liver, Gut, Intestine / intestinal, Colon | Diseases / toxicity: Alzheimer, ALS, Cancer, Tumor, Colon Cancer, Inflammatory bowel disease, IBD | Cell sources: ESC, Stem cell, Stem cells, Cell line, Cell lines, Fibroblast, Epithelial cell | Cell types: Fibroblast, Epithelial cell, Neuron, Enterocyte, Immune cell, T cell, Macrophage | Species: Human, Mouse, Rat, Dog |
| 10.1088/1758-5090/ae2cf2P00462 | 2026 | Review | nlallbr@uw.edu | Study characteristics: Organoid, Organ-on-chip, Biomaterials, Sensors, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Shear stress | Model systems: Organoid, Organ-on-chip, MPS | Organs / tissues: Neural, Liver, Gut, Intestine, Intestine / intestinal, Colon, Muscle | Diseases / toxicity: ALS, Cancer, Tumor, Colon Cancer, Fibrosis, Inflammatory bowel disease | Cell sources: ESC, Primary cell, Stem cell, Stem cells, Cell line, Fibroblast, Epithelial cell | Cell types: Fibroblast, Epithelial cell, Intestinal Stem Cell, Enterocyte, Goblet Cell, Immune cell, T cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.64898/2026.03.25.714163;P00481 | 2026 | Evidence synthesis | l.kutscher@kitz-heidelberg.de | Study characteristics: Organoid, Biomaterials, Omics, Regulatory Language, Validation, iPSC | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid | Organs / tissues: Brain, Neural, Liver, Colon, Bone, Testis, Prostate | Diseases / toxicity: ALS, Glioblastoma, Cancer, Tumor, Leukemia, Infection | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Stem cell, Stem cells, Cell line, Cell lines | Cell types: Neuron, T cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.64898/2026.01.28.702332;P00484 | 2026 | Evidence synthesis | af78@cornell.edu | Study characteristics: Organoid, Biomaterials, Omics, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid | Organs / tissues: Lung, Airway, Liver, Liver / hepatic, Kidney, Intestine / intestinal, Colon | Diseases / toxicity: ALS, Cancer, Tumor, Lung Cancer, Colon Cancer, Prostate Cancer, Leukemia | Cell sources: ESC, Patient-derived, Adult stem cell, Stem cell, Stem cells, Cell line, Cell lines | Cell types: Epithelial cell, T cell, Macrophage | Species: Human, Mouse, Rat |
| 10.1186/s13046-026-03665-yP00494 | 2026 | Review | giovanni.blandino@ifo.it | Study characteristics: Organoid, Drug Testing, Biomaterials, Sensors, Omics, Ai, Regulatory Language | Quantitative reporting: Sample size / replicates | Model systems: Organoid | Organs / tissues: Lung, Kidney, Muscle, Prostate, Breast, Tumor, Immune | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Lung Cancer, Prostate Cancer, Fibrosis | Cell sources: ESC, Patient-derived, Fibroblast, Endothelial cell | Cell types: Endothelial cell, Pericyte, Fibroblast, Immune cell, T cell, Macrophage | Species: Human, Rat, Pig |
| 10.1083/jcb.202211113P00518 | 2026 | Original | boeda@pasteur.fr | Study characteristics: Organoid, Organ-on-chip, Microfluidics, Biomaterials, Sensors, Omics, Ai | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, TEER value | Model systems: Organoid, Organ-on-chip | Organs / tissues: Brain, Neural, Eye, Lung, Heart, Gut, Intestine | Diseases / toxicity: ALS, Cancer, Tumor, Infection | Cell sources: ESC, Stem cell, Stem cells, Cell line, Cell lines, Crispr, Epithelial cell | Cell types: Endothelial cell, Epithelial cell, Astrocyte, T cell, B cell | Species: Human, Mouse, Rat, Dog |
| 10.1039/d6lc00040aP00522 | 2026 | Review | lucio.isa@mat.ethz.ch | Study characteristics: Microfluidics, Biomaterials, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration | Model systems: MPS | Organs / tissues: Colon, Skin | Diseases / toxicity: ALS, Infection, Fibrosis, Cystic Fibrosis | Cell sources: ESC, MSC | Cell types: T cell | Species: Human, Rat |
| 10.1038/s41419-026-08579-3P00526 | 2026 | Review | alessandro.paiardini@uniroma1.it | Study characteristics: Organoid, Drug Testing, Sensors, Omics, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid | Organs / tissues: Lung, Heart, Liver, Prostate, Breast, Tumor | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Lung Cancer, Toxicity | Cell sources: ESC, Patient-derived, Stem cell, Stem cells, Cell line, Cell lines, Epithelial cell | Cell types: Epithelial cell, T cell, B cell | Species: Human, Mouse, Rat |
| 10.1016/j.jcmgh.2026.101784.P00533 | 2026 | Original | sb691007@bcm.edu | Study characteristics: Organoid, Sensors, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid | Organs / tissues: Lung, Intestine, Intestine / intestinal, Immune | Diseases / toxicity: ALS, Infection | Cell sources: ESC, Stem cell, Stem cells | Cell types: Enterocyte, Goblet Cell, Paneth Cell, Tuft Cell, Immune cell, T cell | Species: Human, Mouse, Rat |
| 10.1016/j.rmed.2026.108741P00542 | 2026 | Review | pavel.drevinek@lfmotol.cuni.cz | Study characteristics: Organoid, Biomaterials, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Oxygen concentration, TEER value | Model systems: Organoid | Organs / tissues: Lung, Airway, Liver, Intestine / intestinal, Immune | Diseases / toxicity: ALS, Fibrosis, Cystic Fibrosis | Cell sources: ESC, Patient-derived, Stem cell, Stem cells, Epithelial cell | Cell types: Epithelial cell | Species: Human, Rat |
| 10.1088/1758-5090/ae1d45P00544 | 2026 | Review | martina.brofiga@unige.it | Study characteristics: Organoid, Organ-on-chip, Microfluidics, Drug Testing, Biomaterials, Sensors, Ai | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Spheroid, Assembloid, Organ-on-chip | Organs / tissues: Brain, Cerebral, Neural, Liver, Islet, Bone, Muscle | Diseases / toxicity: Alzheimer, Huntington, ALS, Glioblastoma, Cancer, Tumor, Infection | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Primary cell, Primary cells, Patient-derived | Cell types: Endothelial cell, Pericyte, Astrocyte, Microglia, Oligodendrocyte, Neuron, T cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.1186/s13007-025-01475-5P00566 | 2026 | Original | caroline.bournaud@univ-lyon1.fr | Study characteristics: Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration | Model systems: MPS | Organs / tissues: Eye, Liver, Tumor | Diseases / toxicity: ALS, Cancer, Tumor, Infection | Cell sources: ESC, Cell line, Cell lines, Crispr | Cell types: T cell | Species: Rat, Pig, Dog |
| 10.1128/msphere.00493-25P00569 | 2026 | Evidence synthesis | Katherine.lemon@bcm.edu | Study characteristics: Organoid, Biomaterials, Sensors, Omics, Regulatory Language, Validation, Primary cells | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, TEER value | Model systems: Organoid, MPS | Organs / tissues: Brain, Lung, Airway, Cardiac, Liver, Gut, Intestine / intestinal | Diseases / toxicity: ALS, Cancer, Tumor, COVID-19, Sars Cov, Infection, Fibrosis | Cell sources: ESC, Primary cell, Stem cell, Stem cells, Immortalized, Cell line, Cell lines | Cell types: Epithelial cell, Goblet Cell, Immune cell, T cell, B cell, Macrophage, Dendritic Cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.1038/s41598-026-43243-yP00570 | 2026 | Review | lomax.boyd@gmail.com | Study characteristics: Organoid, MPS, Sensors, Ai, Regulatory Language, Validation | Quantitative reporting: Concentration, Sample size / replicates | Model systems: Organoid, Microphysiological systems | Organs / tissues: Brain, Cerebral, Neural | Diseases / toxicity: ALS | Cell sources: ESC, Stem cell | Cell types: Neuron | Species: Human, Rat |
| 10.1038/s41390-025-04680-zP00574 | 2026 | Evidence synthesis | vbozzetti@mgh.harvard.edu | Study characteristics: Organoid, Biomaterials, Sensors, Omics, Regulatory Language, Validation, Primary cells | Quantitative reporting: Concentration, Time / exposure duration, TEER value | Model systems: Organoid, MPS | Organs / tissues: Brain, Eye, Liver, Gut, Intestine, Intestine / intestinal, Colon | Diseases / toxicity: ALS, Cancer, Colon Cancer, Infection, Toxicity | Cell sources: ESC, Primary cell, Primary cells, Stem cell, Stem cells, Cell line, Epithelial cell | Cell types: Endothelial cell, Vascular endothelial cell, Epithelial cell, Intestinal Stem Cell, Goblet Cell, Immune cell, T cell | Species: Human, Rat, Pig |
| 10.1038/s41380-026-03522-6P00598 | 2026 | Review | moustapha.cisse@univ-nantes.fr | Study characteristics: Organoid, Drug Testing, Biomaterials, Regulatory Language, Validation, iPSC, Multi Organ | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Flow rate, Oxygen concentration | Model systems: Organoid, Spheroid, MPS | Organs / tissues: Brain, Cerebral, Neural, Eye, Liver, Gut, Intestine | Diseases / toxicity: Alzheimer, Parkinson, ALS, Tumor, Infection, Toxicity, Neurotoxicity | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Stem cell, Stem cells, Cell line, Cell lines | Cell types: Epithelial cell, Astrocyte, Microglia, Neuron, T cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.3389/fimmu.2026.1792896P00620 | 2026 | Evidence synthesis | andrea.papait@unicatt.it | Study characteristics: Organoid, Drug Testing, Biomaterials, Regulatory Language, Validation, iPSC | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density, Oxygen concentration | Model systems: Organoid, Spheroid | Organs / tissues: Brain, Cerebral, Neural, Airway, Liver, Colon, Tumor | Diseases / toxicity: Alzheimer, Parkinson, ALS, Glioblastoma, Cancer, Tumor, NASH | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Stem cell, Stem cells, Immortalized, Cell line | Cell types: Endothelial cell, Epithelial cell, Astrocyte, Microglia, Oligodendrocyte, Neuron, Immune cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.3389/fphys.2026.1811508P00652 | 2026 | Evidence synthesis | Katherine.R.Hixon@dartmouth.edu | Study characteristics: Organoid, MPS, Microfluidics, Drug Testing, Biomaterials, Sensors, Ai | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Microphysiological systems, MPS | Organs / tissues: Neural, Alveolar, Liver, Colon, Skin, Bone, Cartilage | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Infection, IBD, Toxicity | Cell sources: iPSC, ESC, Primary cell, Primary cells, Patient-derived, Stem cell, Stem cells | Cell types: Endothelial cell, T cell | Species: Human, Mouse, Rat, Pig, Dog, Non Human Primate, Monkey |
| 10.3389/fimmu.2026.1825593P00658 | 2026 | Review | lhlcaixianlei@nbu.edu.cn | Study characteristics: Organoid, Organ-on-chip, MPS, Microfluidics, Drug Testing, Biomaterials, Sensors | Model systems: Organoid, Spheroid, Organ-on-chip, Organ Chip, Microphysiological systems, MPS | Organs / tissues: Brain, Neural, Eye, Lung, Liver, Kidney / renal, Gut | Diseases / toxicity: ALS, Glioblastoma, Cancer, Tumor, Breast Cancer, Lung Cancer, Pancreatic Cancer | Cell sources: ESC, Primary cell, Patient-derived, Stem cell, Stem cells, Fibroblast, Endothelial cell | Cell types: Hepatocyte, Endothelial cell, Vascular endothelial cell, Pericyte, Fibroblast, Astrocyte, Immune cell | Species: Human, Mouse, Rat | Biomaterials / ECM: Matrigel, Collagen, Collagen I, PDMS, Hydrogel, Scaffold, ECM |
| 10.1016/j.cell.2026.03.009P00659 | 2026 | Review | massimiliano.pagani@ifom.eu | Study characteristics: Organoid, Biomaterials, Omics, Ai, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid, Spheroid, MPS | Organs / tissues: Brain, Lung, Airway, Alveolar, Heart, Cardiac, Liver | Diseases / toxicity: ALS, Glioblastoma, Cancer, Tumor, Breast Cancer | Cell sources: iPSC, ESC, Primary cell, Patient-derived, Stem cell, Stem cells, Cell line | Cell types: Hepatocyte, Endothelial cell, Pericyte, Fibroblast, Epithelial cell, Astrocyte, Microglia | Species: Human, Mouse, Rat, Pig, Dog |
| 10.1038/s41467-026-70550-9P00671 | 2026 | Evidence synthesis | neal.callaghan@dal.ca | Study characteristics: Organoid, Microfluidics, Drug Testing, Biomaterials, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Shear stress | Model systems: Organoid, MPS | Organs / tissues: Brain, Eye, Heart, Cardiac, Muscle, Tumor, Vascular | Diseases / toxicity: ALS, Tumor, Leukemia, Cardiomyopathy, Toxicity, Cardiotoxicity | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Primary cell, Stem cell, Stem cells | Cell types: Cardiomyocyte, Endothelial cell, Pericyte, Neuron, Immune cell, T cell, Macrophage | Species: Human, Mouse, Rat, Pig, Dog |
| 10.3892/ol.2026.15476P00700 | 2026 | Review | lixing@snnu.edu.cn | Study characteristics: Organoid, Microfluidics, Drug Testing, Biomaterials, Sensors, Omics, Regulatory Language | Quantitative reporting: Concentration, Sample size / replicates | Model systems: Organoid, Spheroid, Tumoroid, MPS | Organs / tissues: Brain, Neural, Retina, Lung, Heart, Liver, Liver / hepatic | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Lung Cancer, Colon Cancer, Pancreatic Cancer | Cell sources: ESC, Primary cell, Primary cells, Stem cell, Stem cells, Cell line, Cell lines | Cell types: Hepatocyte, Endothelial cell, Vascular endothelial cell, Fibroblast, Epithelial cell, Immune cell, T cell | Species: Human, Mouse, Rat, Dog |
| 10.3389/fcell.2026.1779410P00701 | 2026 | Evidence synthesis | kqxjsun@163.com | Study characteristics: Organoid, Microfluidics, Biomaterials, Sensors, Omics, Ai, Regulatory Language | Quantitative reporting: Time / exposure duration | Model systems: Organoid, MPS | Organs / tissues: Brain, Neural, Alveolar, Liver, Gut, Intestine / intestinal, Bone | Diseases / toxicity: ALS, Cancer, Tumor, Pancreatic Cancer, Diabetes, Toxicity | Cell sources: ESC, Embryonic Stem Cell, Stem cell, Stem cells, Fibroblast, Epithelial cell, Mesenchymal stem cell | Cell types: Fibroblast, Epithelial cell, T cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.1007/s11010-026-05492-3P00702 | 2026 | Original | yuxinghua@zju.edu.cn | Study characteristics: Organoid, Biomaterials, Omics, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid | Organs / tissues: Liver, Gut, Intestine, Intestine / intestinal, Colon, Tumor, Immune | Diseases / toxicity: ALS, Cancer, Tumor, Inflammatory bowel disease, IBD, Toxicity | Cell sources: ESC, Patient-derived, Stem cell, Stem cells, Crispr | Cell types: Intestinal Stem Cell, Enterocyte, Goblet Cell, Paneth Cell, Immune cell, T cell | Species: Human, Mouse, Rat, Dog |
| 10.1038/s42003-026-09864-9P00706 | 2026 | Evidence synthesis | Ujjwal.neogi@ki.se | Study characteristics: Organoid, Biomaterials, Omics, Regulatory Language, Validation, iPSC | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid | Organs / tissues: Brain, Cerebral, Neural, Liver / hepatic, Gut, Colon, Vascular | Diseases / toxicity: Alzheimer, Huntington, ALS, Infection, Toxicity, Neurotoxicity | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Stem cell, Stem cells, Immortalized, Cell line | Cell types: Astrocyte, Microglia, Oligodendrocyte, Neuron, Immune cell, T cell, B cell | Species: Human, Rat, Pig |
| 10.3389/fphys.2026.1734890P00750 | 2026 | Evidence synthesis | mario.cazzola@uniroma2.it | Study characteristics: Organoid, Biomaterials, Omics, Ai, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Sample size / replicates | Model systems: Organoid, MPS | Organs / tissues: Neural, Eye, Lung, Airway, Alveolar, Heart, Cardiac | Diseases / toxicity: ALS, Cancer, Tumor, COVID-19, Sars Cov, Infection, Fibrosis | Cell sources: ESC, Patient-derived, Stem cell, Stem cells, Crispr, Fibroblast, Epithelial cell | Cell types: Endothelial cell, Vascular endothelial cell, Fibroblast, Epithelial cell, Immune cell, T cell, B cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.3390/bios16030172P00755 | 2026 | Evidence synthesis | nuricaglayan@akdeniz.edu.tr | Study characteristics: Organoid, Organ-on-chip, Microfluidics, Biomaterials, Sensors, Ai, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Organ-on-chip, Lab-on-chip | Organs / tissues: Eye, Liver, Skin, Bone, Tumor, Vascular | Diseases / toxicity: ALS, Tumor, COVID-19 | Cell sources: ESC | Species: Human, Rat | Biomaterials / ECM: Alginate, Hydrogel, BME |
| 10.1038/s41598-026-46184-8P00775 | 2026 | Original | sam.forster@hudson.org.au | Study characteristics: Organoid, Biomaterials, Omics, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Assembloid | Organs / tissues: Liver, Kidney / renal, Gut, Intestine, Intestine / intestinal, Colon, Tumor | Diseases / toxicity: ALS, Cancer, Tumor, Infection, NASH, Inflammatory bowel disease, IBD | Cell sources: ESC, Patient-derived, Stem cell, Stem cells, Cell line, Cell lines, Epithelial cell | Cell types: Epithelial cell, Intestinal Stem Cell, Enterocyte, Goblet Cell, Immune cell, T cell, Macrophage | Species: Human, Mouse, Rat, Pig |
| 10.1038/s41564-026-02297-4P00791 | 2026 | Review | christopher.stewart@newcastle.ac.uk | Study characteristics: Organoid, Drug Testing, Biomaterials, Sensors, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density, TEER value | Model systems: Organoid, MPS | Organs / tissues: Brain, Neural, Eye, Heart, Liver, Gut, Intestine | Diseases / toxicity: ALS, Infection, Inflammatory bowel disease, Crohn disease, Toxicity | Cell sources: ESC, Cell line, Cell lines, Epithelial cell | Cell types: Epithelial cell, Enterocyte, Goblet Cell, Immune cell, T cell | Species: Human, Mouse, Rat, Dog |
| 10.3389/fcell.2026.1710021P00802 | 2026 | Review | badrul@usm.my | Study characteristics: Organoid, Biomaterials, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Spheroid, MPS | Organs / tissues: Lung, Airway, Alveolar, Cardiac, Kidney / renal, Bone, Muscle | Diseases / toxicity: Alzheimer, Parkinson, ALS, Cancer, Lung Cancer, COVID-19, Fibrosis | Cell sources: ESC, Stem cell, Stem cells, Fibroblast, Epithelial cell, Mesenchymal stem cell, MSC | Cell types: Fibroblast, Epithelial cell, Microglia, Podocyte, Mesangial Cell, Immune cell, T cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.1186/1471-2164-15-539P00810 | 2026 | Evidence synthesis | petang@mail.cgu.edu.tw | Study characteristics: Regulatory Language, Validation | Organs / tissues: Eye, Prostate, Tumor | Diseases / toxicity: ALS, Cancer, Tumor, Prostate Cancer | Cell sources: ESC, Stem cell, Stem cells | Cell types: T cell, B cell, Macrophage | Species: Human, Mouse, Rat, Zebrafish, Pig | Biomaterials / ECM: BME | Chip materials: Glass |
| 10.1038/s41378-020-0160-4P00816 | 2026 | Review | caoyunxia6@126.com | Study characteristics: Microfluidics, Biomaterials, Sensors, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: MPS | Organs / tissues: Neural, Lung, Islet, Ovary, Vascular, Immune | Diseases / toxicity: ALS, Cancer, Lung Cancer, Toxicity | Cell sources: ESC, Embryonic Stem Cell, Stem cell, Stem cells, Endothelial cell | Cell types: Endothelial cell, Immune cell, T cell | Species: Human, Mouse, Rat, Dog, Monkey |
| 10.3389/fcell.2024.1412337P00833 | 2026 | Evidence synthesis | drlhao@163.com | Study characteristics: Organoid, Organ-on-chip, Drug Testing, Biomaterials, Omics, Regulatory Language, Patient-derived | Quantitative reporting: Concentration, Sample size / replicates | Model systems: Organoid, Spheroid, Organ-on-chip, MPS | Organs / tissues: Brain, Eye, Lung, Liver, Kidney, Gut, Intestine / intestinal | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Colon Cancer, Pancreatic Cancer, Prostate Cancer | Cell sources: Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Patient-derived, Stem cell, Stem cells, Immortalized | Cell types: Hepatocyte, Endothelial cell, Vascular endothelial cell, Fibroblast, Epithelial cell, Neuron, Immune cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.1038/s41467-025-61441-6P00848 | 2026 | Review | magdaz@caltech.edu | Study characteristics: Organoid, Biomaterials, Omics, Ai, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, MPS | Organs / tissues: Neural, Eye, Skin, Bone, Placenta | Diseases / toxicity: ALS, Cancer | Cell sources: ESC, Embryonic Stem Cell, Stem cell, Stem cells, Cell line, Epithelial cell, Endothelial cell | Cell types: Endothelial cell, Epithelial cell, T cell | Species: Human, Mouse, Rat, Pig, Dog, Monkey |
| 10.3389/fbioe.2025.1716071P00854 | 2026 | Review | fupan@nimte.ac.cn | Study characteristics: Organoid, Drug Testing, Biomaterials, Sensors, Omics, Ai, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Spheroid, Assembloid | Organs / tissues: Brain, Cerebral, Neural, Retina, Eye, Heart, Cardiac | Diseases / toxicity: ALS, Cancer, Tumor, Infection, Toxicity | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Patient-derived, Stem cell, Stem cells, Epithelial cell | Cell types: Endothelial cell, Epithelial cell, Neuron, Immune cell, T cell, Macrophage, NK cell | Species: Human, Mouse, Rat |
| 10.1186/s13046-025-03557-7P00855 | 2026 | Review | liyam@upstate.edu | Study characteristics: Organoid, Drug Testing, Biomaterials, Omics, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Tumoroid | Organs / tissues: Lung, Heart, Liver, Kidney, Gut, Colon, Tumor | Diseases / toxicity: ALS, Glioblastoma, Cancer, Tumor, Lung Cancer, Infection, Toxicity | Cell sources: ESC, Patient-derived, Immortalized, Cell line, Cell lines | Cell types: Immune cell, T cell, Dendritic Cell | Species: Human, Mouse, Rat, Pig |
| 10.1186/s40001-026-03852-9P00896 | 2026 | Review | suwenmei123@hotmail.com | Study characteristics: Organoid, Microfluidics, Biomaterials, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid | Organs / tissues: Lung, Liver, Kidney, Kidney / renal, Intestine / intestinal, Breast, Tumor | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Lung Cancer, Infection, Fibrosis | Cell sources: ESC, Cell line, Cell lines, Fibroblast, Endothelial cell | Cell types: Endothelial cell, Fibroblast, Neuron, Immune cell, T cell, Macrophage | Species: Human, Rat, Pig |
| 10.3390/ijms27052211P00897 | 2026 | Review | bcchen1@student.unimelb.edu.au | Study characteristics: Organoid, Biomaterials, Omics, Regulatory Language, Validation, Primary cells | Quantitative reporting: Concentration, Time / exposure duration | Model systems: Organoid, MPS | Organs / tissues: Lung, Gut, Colon, Skin, Placenta, Tumor, Immune | Diseases / toxicity: ALS, Cancer, Tumor, Fibrosis, Ulcerative Colitis | Cell sources: ESC, Primary cell, Primary cells, Cell line, Cell lines, Fibroblast, Epithelial cell | Cell types: Fibroblast, Epithelial cell, Immune cell, T cell, Macrophage | Species: Human, Mouse, Rat, Pig, Dog |
| 10.1038/s41565-025-02082-0P00898 | 2026 | Evidence synthesis | bailong@shu.edu.cn | Study characteristics: Organoid, Microfluidics, Biomaterials, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Spheroid, MPS | Organs / tissues: Lung, Heart, Liver, Kidney, Skin, Bone, Cartilage | Diseases / toxicity: ALS, Cancer, Tumor, Infection, Toxicity | Cell sources: ESC, Stem cell, Stem cells | Cell types: T cell, Macrophage | Species: Human, Mouse, Rat, Dog |
| 10.62347/cbmb4249P00902 | 2026 | Original | 15021119180@163.com | Study characteristics: Validation | Quantitative reporting: Time / exposure duration | Organs / tissues: Lung, Alveolar, Gut, Vascular | Diseases / toxicity: ALS, COVID-19, Infection | Cell sources: ESC | Cell types: T cell | Species: Human, Rat | Chip materials: COC |
| 10.1186/s11671-025-04328-1P00904 | 2026 | Review | zhuxin@zjcc.org.cn | Study characteristics: Organoid, Microfluidics, Biomaterials, Sensors, Omics, Ai, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration | Model systems: Organoid | Organs / tissues: Eye, Heart, Cardiac, Liver, Kidney / renal, Gut, Colon | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Colon Cancer, Pancreatic Cancer, Prostate Cancer | Cell sources: ESC, Stem cell, Stem cells, Cell line, Cell lines, Fibroblast, Epithelial cell | Cell types: Fibroblast, Epithelial cell, Immune cell, T cell, B cell, NK cell | Species: Human, Mouse, Rat, Zebrafish, Pig |
| 10.1039/d4sc08375jP00924 | 2026 | Review | daniel.chevrier@cea.fr | Study characteristics: Biomaterials, Omics, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Oxygen concentration | Organs / tissues: Eye, Gut, Skin | Diseases / toxicity: ALS, NASH | Cell sources: ESC, MSC | Species: Human, Rat | Biomaterials / ECM: PDMS | Chip materials: PDMS, COC, Glass, Silicon |
| 10.1038/s41421-022-00422-1P00941 | 2026 | Review | shibojiang@fudan.edu.cn | Study characteristics: Organoid, Biomaterials, Sensors, Omics, Regulatory Language, Primary cells | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid | Organs / tissues: Lung, Airway, Alveolar, Gut, Intestine / intestinal, Colon, Immune | Diseases / toxicity: ALS, COVID-19, Sars Cov, Infection | Cell sources: ESC, Embryonic Stem Cell, Primary cell, Primary cells, Adult stem cell, Stem cell, Stem cells | Cell types: Epithelial cell, Enterocyte, Goblet Cell, T cell, B cell | Species: Human, Mouse, Rat, Pig |
| 10.3390/ani16020232P00943 | 2026 | Evidence synthesis | malgorzata.chmielewska@uwm.edu.pl | Study characteristics: Organoid, Biomaterials, Regulatory Language, Validation | Quantitative reporting: Time / exposure duration | Model systems: Organoid | Organs / tissues: Brain, Retina, Eye, Lung, Heart, Cardiac, Liver | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Lung Cancer, Infection, Fibrosis | Cell sources: ESC, Stem cell, Stem cells, Cell line, Cell lines, Epithelial cell | Cell types: Epithelial cell, T cell, Macrophage | Species: Human, Mouse, Rat, Zebrafish, Pig, Dog, Non Human Primate |
| 10.3389/fbioe.2021.697657P00946 | 2026 | Original | bianne20@gmail.com | Study characteristics: Organoid, Microfluidics, Drug Testing, Biomaterials, Sensors, Omics, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Seeding density | Model systems: Organoid, Spheroid | Organs / tissues: Brain, Eye, Airway, Liver, Colon, Breast, Tumor | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Colon Cancer, Diabetes | Cell sources: ESC, Cell line, Cell lines, Endothelial cell | Cell types: Endothelial cell, Vascular endothelial cell, Immune cell, T cell | Species: Human, Mouse, Rat |
| 10.12122/j.issn.1673-4254.2025.04.17P00971 | 2026 | Original | fiona1215@aliyun.com | Study characteristics: Organoid, Biomaterials, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid | Organs / tissues: Brain, Cerebral, Liver, Gut, Intestine / intestinal, Colon, Tumor | Diseases / toxicity: ALS, Tumor, Inflammatory bowel disease, IBD, Crohn disease, Ulcerative Colitis | Cell sources: ESC, Epithelial cell | Cell types: Epithelial cell, Neuron, Goblet Cell, T cell, Macrophage | Species: Mouse, Rat, Pig |
| 10.1038/s41467-024-52886-2P00980 | 2026 | Evidence synthesis | vermulst@usc.edu | Study characteristics: Organoid, Biomaterials, Omics, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density, Oxygen concentration | Model systems: Organoid, MPS | Organs / tissues: Brain, Neural, Eye, Lung, Heart, Cardiac, Kidney | Diseases / toxicity: Alzheimer, Parkinson, ALS, Glioblastoma, Cancer, Tumor, Infection | Cell sources: ESC, Embryonic Stem Cell, Stem cell, Stem cells, Cell line, Cell lines, Crispr | Cell types: Neuron, T cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.3390/bioengineering9110718P00998 | 2026 | Review | benedicte.charrier@cnrs.fr | Study characteristics: Microfluidics, Biomaterials, Sensors, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Shear stress | Model systems: MPS, Lab-on-chip | Diseases / toxicity: ALS | Cell sources: ESC, Crispr | Cell types: Neuron, T cell | Species: Rat, Pig | Biomaterials / ECM: Alginate, PEG, PDMS, BME |
| 10.3390/cancers17132102P01010 | 2026 | Evidence synthesis | giovanni.colonna@unicampania.it | Study characteristics: Organoid, Drug Testing, Biomaterials, Sensors, Omics, Ai, Regulatory Language | Model systems: Organoid, MPS | Organs / tissues: Brain, Neural, Eye, Lung, Liver, Kidney, Kidney / renal | Diseases / toxicity: Alzheimer, ALS, Glioblastoma, Cancer, Tumor, Breast Cancer, Lung Cancer | Cell sources: ESC, Patient-derived, Adult stem cell, Stem cell, Stem cells, Cell line, Cell lines | Cell types: Endothelial cell, Fibroblast, Immune cell, T cell, Macrophage | Species: Human, Mouse, Rat, Pig, Dog | Drugs / perturbagens: Erlotinib, Gefitinib, Imatinib, Pembrolizumab, Nivolumab, Ipilimumab |
| 10.1093/hmg/ddaf029P01048 | 2026 | Original | j.serrano@ucl.ac.uk | Study characteristics: Organoid, Ai, Regulatory Language, Validation, Patient-derived, iPSC | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Shear stress | Model systems: Organoid | Organs / tissues: Brain, Neural, Retina, Eye, Liver, Kidney, Pancreas | Diseases / toxicity: ALS | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Patient-derived, Stem cell, Stem cells, Fibroblast | Cell types: Fibroblast, T cell | Species: Human, Mouse, Rat, Zebrafish, Pig, Dog |
| 10.1371/journal.pone.0026002P01053 | 2026 | Original | Rene_Cortese@camh.net | Study characteristics: Regulatory Language, Validation | Quantitative reporting: Time / exposure duration, Sample size / replicates | Organs / tissues: Brain, Neural, Heart, Liver, Kidney, Muscle, Breast | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Toxicity | Cell sources: ESC, Embryonic Stem Cell, Stem cell, Stem cells, Cell line, Cell lines | Cell types: T cell, Macrophage | Species: Human, Mouse, Rat, Pig | Biomaterials / ECM: Agarose |
| 10.3389/fendo.2025.1538463P01073 | 2026 | Review | eet@austin.utexas.edu | Study characteristics: Organoid, Biomaterials, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Spheroid | Organs / tissues: Eye, Liver, Liver / hepatic, Kidney, Gut, Intestine, Intestine / intestinal | Diseases / toxicity: ALS, Cancer, Tumor, Colon Cancer, Diabetes, Steatosis, Ulcerative Colitis | Cell sources: ESC, Adult stem cell, Stem cell, Stem cells, Cell line, Cell lines, Epithelial cell | Cell types: Epithelial cell, Intestinal Stem Cell, Enterocyte, Goblet Cell, Immune cell, T cell | Species: Human, Mouse, Rat, Pig |
| 10.1002/stem.3325P01079 | 2026 | Original | j.sowden@ucl.ac.uk | Study characteristics: Organoid, Biomaterials, Omics, Regulatory Language, Patient-derived, iPSC | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid | Organs / tissues: Brain, Neural, Retina, Eye, Liver, Gut, Colon | Diseases / toxicity: ALS | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Patient-derived, Stem cell, Stem cells | Cell types: Fibroblast, Astrocyte, Neuron, T cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.1038/s41598-025-22669-wP01080 | 2026 | Review | doretta.cuffaro@unipi.it | Study characteristics: Organoid, Microfluidics, Biomaterials, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid, Spheroid, Assembloid | Organs / tissues: Lung, Liver, Intestine / intestinal, Colon, Bone, Tumor, Vascular | Diseases / toxicity: ALS, Cancer, Tumor, Lung Cancer, Colon Cancer, Leukemia, Toxicity | Cell sources: ESC, Patient-derived, Stem cell, Cell line, Cell lines, Fibroblast, Epithelial cell | Cell types: Endothelial cell, Fibroblast, Epithelial cell, Immune cell, T cell, B cell, Macrophage | Species: Human, Mouse, Rat, Pig, Dog |
| 10.5483/bmbrep.2022.55.5.043P01081 | 2026 | Review | seungwoocho@yonsei.ac.kr | Study characteristics: Organoid, Organ-on-chip, MPS, Microfluidics, Drug Testing, Biomaterials, Sensors | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Oxygen concentration | Model systems: Organoid, Spheroid, Organ-on-chip, Organ Chip, Microphysiological systems, MPS, Multi-organ chip | Organs / tissues: Brain, Cerebral, Neural, Retina, Eye, Lung, Liver | Diseases / toxicity: Alzheimer, ALS, Glioblastoma, Cancer, Tumor, COVID-19, Sars Cov | Cell sources: Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Patient-derived, Stem cell, Stem cells, Endothelial cell | Cell types: Endothelial cell, Pericyte, Astrocyte, Microglia, Neuron, T cell | Species: Human, Mouse, Rat, Zebrafish |
| 10.1371/journal.pone.0023219P01082 | 2026 | Original | husn@big.ac.cn | Study characteristics: Omics, Regulatory Language, Validation | Quantitative reporting: Concentration | Model systems: MPS | Organs / tissues: Brain, Eye, Intestine / intestinal, Testis | Diseases / toxicity: ALS, Cancer | Cell sources: ESC, Embryonic Stem Cell, Stem cell | Cell types: T cell | Species: Human, Mouse, Rat, Pig |
| 10.1186/s13619-021-00102-7P01083 | 2026 | Review | jhqin@dicp.ac.cn | Study characteristics: Organoid, Microfluidics, Biomaterials, Omics, Regulatory Language, Validation, iPSC | Quantitative reporting: Concentration, Time / exposure duration | Model systems: Organoid | Organs / tissues: Brain, Neural, Lung, Liver, Colon, Skin, Bone | Diseases / toxicity: ALS, Glioblastoma, Cancer, Tumor, Breast Cancer, Lung Cancer, Colon Cancer | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Stem cell, Stem cells, Cell line, Fibroblast | Cell types: Fibroblast, Neuron, T cell, NK cell | Species: Human, Mouse, Rat |
| 10.1038/s41531-024-00799-8P01084 | 2026 | Evidence synthesis | xuyuming@zzu.edu.cn | Study characteristics: Organoid, MPS, Drug Testing, Sensors, Omics, Ai, Regulatory Language | Quantitative reporting: Time / exposure duration | Model systems: Organoid, Spheroid, Assembloid, Microphysiological systems | Organs / tissues: Brain, Cerebral, Neural, Retina, Liver, Kidney, Gut | Diseases / toxicity: Alzheimer, Parkinson, Huntington, ALS, Tumor, Toxicity, Neurotoxicity | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Patient-derived, Stem cell, Stem cells | Cell types: Astrocyte, Microglia, Oligodendrocyte, Neuron, Dopaminergic Neuron, Motor Neuron, Immune cell | Species: Human, Mouse, Rat, Pig, Dog, Non Human Primate, Monkey |
| 10.7150/ijbs.109593P01085 | 2026 | Review | yujany_zhou@163.com | Study characteristics: Organoid, Biomaterials, Omics, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Time / exposure duration | Model systems: Organoid, MPS | Organs / tissues: Brain, Lung, Cardiac, Liver, Liver / hepatic, Kidney / renal, Colon | Diseases / toxicity: ALS, Glioblastoma, Cancer, Tumor, Breast Cancer, Lung Cancer, Colon Cancer | Cell sources: ESC, Embryonic Stem Cell, Patient-derived, Stem cell, Stem cells, Cell line, Cell lines | Cell types: Endothelial cell, Fibroblast, Neuron, Motor Neuron, Immune cell, T cell, B cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.3390/microorganisms13061281P01086 | 2026 | Evidence synthesis | cuibaoqiu1314@hotmail.com | Study characteristics: Organoid, Microfluidics, Drug Testing, Biomaterials, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration | Model systems: Organoid, MPS | Organs / tissues: Brain, Cerebral, Neural, Eye, Liver, Gut, Skin | Diseases / toxicity: ALS, Cancer, COVID-19, Sars Cov, Infection, NASH, Toxicity | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Stem cell, Stem cells, Cell line | Cell types: Endothelial cell, Vascular endothelial cell, Pericyte, Fibroblast, Epithelial cell, Astrocyte, Microglia | Species: Human, Mouse, Rat, Pig, Monkey |
| 10.1038/s41698-026-01358-5P01087 | 2026 | Review | xiaomengsong@njmu.edu.cn | Study characteristics: Organoid, Drug Testing, Biomaterials, Sensors, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, MPS | Organs / tissues: Lung, Liver / hepatic, Colon, Breast, Tumor, Immune | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Lung Cancer, Colon Cancer, Toxicity | Cell sources: ESC, Patient-derived, Stem cell, Stem cells, Cell line, Cell lines | Cell types: Immune cell, T cell, Macrophage | Species: Human, Mouse, Rat, Pig, Dog |
| 10.3389/fcell.2025.1564847P01089 | 2026 | Review | moumita.barua@uhn.ca | Study characteristics: Organoid, Microfluidics, Drug Testing, Biomaterials, Sensors, Omics, Regulatory Language | Quantitative reporting: Concentration, Sample size / replicates | Model systems: Organoid | Organs / tissues: Neural, Eye, Liver, Kidney, Kidney / renal, Gut, Bone | Diseases / toxicity: ALS, Cancer, Tumor, Fibrosis, Diabetes, Kidney Injury, Toxicity | Cell sources: iPSC, ESC, Stem cell, Stem cells, Crispr, Fibroblast, Epithelial cell | Cell types: Cardiomyocyte, Endothelial cell, Fibroblast, Epithelial cell, Neuron, Podocyte, Mesangial Cell | Species: Human, Mouse, Rat, Zebrafish |
| 10.1371/journal.pgen.1001014P01090 | 2026 | Original | furlong@embl.de | Study characteristics: Regulatory Language | Quantitative reporting: Time / exposure duration | Organs / tissues: Brain, Neural, Cardiac, Gut, Bone, Muscle, Immune | Diseases / toxicity: ALS, Cancer | Cell sources: ESC | Cell types: T cell | Species: Rat, Zebrafish, Dog | Media: MEM |
| 10.1038/micronano.2017.28P01092 | 2026 | Review | vincenzo.curto@emse.fr | Study characteristics: Organoid, Organ-on-chip, Microfluidics, Drug Testing, Biomaterials, Sensors, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Organ-on-chip | Organs / tissues: Brain, Eye, Lung, Liver, Kidney, Kidney / renal, Intestine | Diseases / toxicity: ALS, Tumor, Toxicity, Nephrotoxicity | Cell sources: ESC, Stem cell, Stem cells, Epithelial cell | Cell types: Epithelial cell, T cell | Species: Human, Rat, Dog |
| 10.3389/fcell.2021.640633P01093 | 2026 | Review | J.Drost@prinsesmaximacentrum.nl | Study characteristics: Organoid, Omics, Regulatory Language, Validation, Patient-derived, iPSC | Quantitative reporting: Concentration | Model systems: Organoid, MPS | Organs / tissues: Brain, Cerebral, Neural, Retina, Eye, Liver, Kidney | Diseases / toxicity: ALS, Glioblastoma, Cancer, Tumor, Pancreatic Cancer | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Patient-derived, Adult stem cell, Stem cell | Cell types: Hepatocyte, Astrocyte, Oligodendrocyte, Neuron, T cell | Species: Human, Mouse, Rat, Pig |
| 10.1101/2025.09.24.677447;P01096 | 2026 | Evidence synthesis | spencejr@med.umich.edu | Study characteristics: Organoid, MPS, Drug Testing, Biomaterials, Sensors, Omics, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, TEER value | Model systems: Organoid, Spheroid, Microphysiological systems | Organs / tissues: Eye, Liver, Kidney, Gut, Intestine, Intestine / intestinal, Colon | Diseases / toxicity: ALS, Cancer, Tumor, Infection, Diabetes, Crohn disease, Ulcerative Colitis | Cell sources: ESC, Stem cell, Stem cells, Cell line, Cell lines, Fibroblast, Epithelial cell | Cell types: Fibroblast, Epithelial cell, Intestinal Stem Cell, Goblet Cell, Immune cell, T cell, Macrophage | Species: Human, Mouse, Rat, Dog |
| 10.1039/d1lc00271fP01106 | 2026 | Original | yysh2@cam.ac.uk | Study characteristics: Organoid, Microfluidics, Drug Testing, Biomaterials, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Seeding density | Model systems: Organoid, Spheroid, MPS | Organs / tissues: Brain, Neural, Eye, Lung, Skin, Tumor, Vascular | Diseases / toxicity: ALS, Glioblastoma, Cancer, Tumor, Toxicity | Cell sources: ESC, Patient-derived, Stem cell, Stem cells, Cell line, Cell lines, Endothelial cell | Cell types: Endothelial cell, Vascular endothelial cell, T cell | Species: Human, Rat, Pig |
| 10.3389/fbioe.2023.1237561P01107 | 2026 | Evidence synthesis | renan.leonel@hest.ethz.ch | Study characteristics: Organoid, Organ-on-chip, MPS, Biomaterials, Regulatory Language, Validation | Quantitative reporting: Concentration, Sample size / replicates | Model systems: Organoid, Organ-on-chip, Organ Chip, Microphysiological systems, MPS | Organs / tissues: Lung, Liver, Kidney, Immune | Diseases / toxicity: ALS, Cancer, COVID-19, Toxicity | Cell sources: ESC, Adult stem cell, Stem cell, Stem cells, Cell line, Cell lines | Cell types: Neuron, Immune cell, T cell | Species: Human, Rat |
| 10.3390/mi16070757P01108 | 2026 | Review | fsp.silva@unesp.br | Study characteristics: Microfluidics, Regulatory Language, Validation | Quantitative reporting: Concentration | Diseases / toxicity: ALS | Cell sources: ESC | Species: Rat | Biomaterials / ECM: Alginate, BME | Chip materials: COC | Markers: ALT, AST |
| 10.1101/2025.08.05.668554;P01109 | 2026 | Evidence synthesis | ioana.ni@gmail.com | Study characteristics: Organoid, Microfluidics, Drug Testing, Biomaterials, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density, Flow rate, Oxygen concentration | Model systems: Organoid, MPS | Organs / tissues: Brain, Cerebral, Airway, Heart, Cardiac, Liver, Liver / hepatic | Diseases / toxicity: Alzheimer, Parkinson, Huntington, ALS, Cancer, Tumor, Breast Cancer | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Primary cell, Primary cells, Patient-derived | Cell types: Endothelial cell, Fibroblast, Astrocyte, Microglia, Neuron, Dopaminergic Neuron, Immune cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.1021/acsbiomaterials.4c02221P01110 | 2026 | Evidence synthesis | latorre@feq.unicamp.br | Study characteristics: Organoid, Organ-on-chip, MPS, Microfluidics, Drug Testing, Biomaterials, Sensors | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Shear stress, TEER value | Model systems: Organoid, Spheroid, Organ-on-chip, Organ Chip, Microphysiological systems, MPS, Multi-organ chip | Organs / tissues: Brain, Cerebral, Neural, Retina, Eye, Lung, Airway | Diseases / toxicity: Alzheimer, Parkinson, Huntington, ALS, Glioblastoma, Cancer, Tumor | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Stem cell, Stem cells, Cell line, Cell lines | Cell types: Endothelial cell, Vascular endothelial cell, Pericyte, Epithelial cell, Astrocyte, Microglia, Oligodendrocyte | Species: Human, Mouse, Rat |
| 10.1371/journal.pone.0328278P01111 | 2026 | Evidence synthesis | anakaroline.alms@gmail.com | Study characteristics: Organoid, Organ-on-chip, Microfluidics, Drug Testing, Biomaterials, Sensors, Omics | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid, Spheroid, Organ-on-chip, Organ Chip, MPS | Organs / tissues: Lung, Liver, Liver / hepatic, Intestine / intestinal, Pancreas, Islet, Skin | Diseases / toxicity: ALS, Tumor, COVID-19, Infection, Fibrosis, Diabetes | Cell sources: ESC, Primary cell, Primary cells, Patient-derived, Stem cell, Stem cells, Cell line | Cell types: Hepatocyte, Endothelial cell, Vascular endothelial cell, Fibroblast, Epithelial cell, Podocyte, Immune cell | Species: Human, Mouse, Rat, Dog |
| 10.1038/s41598-021-84852-zP01115 | 2026 | Original | — | Study characteristics: Organoid, Drug Testing, Biomaterials, Sensors, Omics, Ai, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid | Organs / tissues: Lung, Heart, Liver, Colon, Muscle, Breast, Tumor | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Lung Cancer, Pancreatic Cancer, Toxicity | Cell sources: ESC, Patient-derived, Stem cell, Cell line, Cell lines, Fibroblast, Endothelial cell | Cell types: Endothelial cell, Fibroblast, Beta cell, T cell | Species: Human, Mouse, Rat, Dog |
| 10.3389/fimmu.2025.1467357P01119 | 2026 | Review | lxdr21@126.com | Study characteristics: Organoid, Biomaterials, Omics, Ai, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density, Pore size | Model systems: Organoid | Organs / tissues: Eye, Lung, Liver, Kidney / renal, Colon, Skin, Bone | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Lung Cancer, Prostate Cancer, Infection | Cell sources: ESC, Cell line, Cell lines, Fibroblast, Epithelial cell, Endothelial cell | Cell types: Endothelial cell, Fibroblast, Epithelial cell, Immune cell, T cell, B cell, Macrophage | Species: Human, Mouse, Rat, Dog |
| 10.1161/atvbaha.125.322829.P01122 | 2026 | Original | jtb47@cornell.edu | Study characteristics: Organoid, Microfluidics, Biomaterials, Sensors, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Shear stress | Model systems: Organoid | Organs / tissues: Neural, Retina, Eye, Heart, Cardiac, Bone, Cartilage | Diseases / toxicity: ALS, Cardiomyopathy | Cell sources: ESC, Cell line, Fibroblast, Endothelial cell | Cell types: Cardiac fibroblast, Endothelial cell, Fibroblast, T cell, B cell | Species: Human, Mouse, Rat, Zebrafish, Pig |
| 10.1038/s41467-024-53973-0P01123 | 2026 | Review | pmali@ucsd.edu | Study characteristics: Organoid, Omics, Regulatory Language, Validation, iPSC | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, MPS | Organs / tissues: Brain, Cerebral, Neural, Retina, Airway, Heart, Cardiac | Diseases / toxicity: ALS, Cancer, Infection | Cell sources: iPSC, ESC, Stem cell, Stem cells, Cell line, Cell lines, Crispr | Cell types: Pericyte, Fibroblast, Astrocyte, Neuron, T cell | Species: Human, Mouse, Rat, Dog |
| 10.1038/lsa.2017.121P01125 | 2026 | Review | ozcan@ucla.edu | Study characteristics: Sensors, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: MPS | Organs / tissues: Eye, Skin | Diseases / toxicity: ALS | Cell sources: ESC, Stem cell, Stem cells | Species: Human, Rat, Dog | Chip materials: COC, Glass |
| 10.1172/jci.P01127 | 2026 | Review | senad.divanovic@cchmc.org | Study characteristics: Organoid, Biomaterials, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid | Organs / tissues: Brain, Lung, Heart, Liver, Liver / hepatic, Bone, Breast | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Lung Cancer, Leukemia, Infection | Cell sources: ESC, Stem cell, Stem cells, Mesenchymal stem cell | Cell types: Immune cell, T cell, Macrophage, Dendritic Cell, NK cell | Species: Human, Mouse, Rat |
| 10.3390/s19214692P01132 | 2026 | Review | dantism@fh-aachen.de | Study characteristics: Microfluidics, Sensors, Regulatory Language, Multi Organ | Quantitative reporting: Concentration, Time / exposure duration | Organs / tissues: Kidney / renal, Intestine / intestinal, Colon, Bone | Diseases / toxicity: ALS | Cell sources: ESC | Cell types: T cell | Species: Human, Rat | Biomaterials / ECM: BME |
| 10.1183/16000617.0229-2025P01139 | 2026 | Review | permissions@ersnet.org | Study characteristics: Organoid, Regulatory Language, iPSC | Model systems: Organoid | Organs / tissues: Cerebral, Lung, Liver, Tumor | Diseases / toxicity: ALS, Tumor | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Stem cell, Stem cells | Species: Human, Rat, Pig | Markers: ALT, AST | Imaging: TEM |
| 10.3389/fnmol.2024.1371733P01145 | 2026 | Review | erin.knock@stemcell.com | Study characteristics: Organoid, Organ-on-chip, MPS, Microfluidics, Biomaterials, Sensors, Omics | Quantitative reporting: Time / exposure duration | Model systems: Organoid, Organ-on-chip, Microphysiological systems | Organs / tissues: Brain, Cerebral, Liver, Vascular, Blood-brain barrier, BBB, Immune | Diseases / toxicity: Parkinson, ALS, COVID-19, Infection | Cell sources: iPSC, Induced Pluripotent Stem Cell, Stem cell, Stem cells, Endothelial cell, hiPSC | Cell types: Endothelial cell, Vascular endothelial cell, Astrocyte, Microglia, Neuron, Immune cell, T cell | Species: Human, Mouse, Rat |
| 10.1186/s12885-024-13187-5P01146 | 2026 | Review | jktailor@iu.edu | Study characteristics: Organoid, Drug Testing, Biomaterials, Regulatory Language, Validation, Patient-derived, iPSC | Quantitative reporting: Time / exposure duration | Model systems: Organoid, MPS | Organs / tissues: Brain, Cerebral, Neural, Eye, Liver, Tumor, Vascular | Diseases / toxicity: ALS, Glioblastoma, Cancer, Tumor, Diabetes | Cell sources: Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Patient-derived, Stem cell, Stem cells, Immortalized | Cell types: Endothelial cell, Fibroblast, Epithelial cell, Astrocyte, Microglia, Neuron, Immune cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.3389/fbioe.2020.00163P01162 | 2026 | Original | giorgia.imparato@iit.it | Study characteristics: Organ-on-chip, MPS, Microfluidics, Drug Testing, Biomaterials, Sensors, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Flow rate, Shear stress | Model systems: Organ-on-chip, Microphysiological systems | Organs / tissues: Brain, Liver, Liver / hepatic, Gut, Intestine, Intestine / intestinal, Colon | Diseases / toxicity: ALS, Steatosis, Toxicity, Hepatotoxicity | Cell sources: ESC, Cell line, Fibroblast, Epithelial cell | Cell types: Hepatocyte, Fibroblast, Epithelial cell, Enterocyte, T cell | Species: Human, Mouse, Rat, Dog |
| 10.1101/2025.02.25.640132;P01178 | 2026 | Evidence synthesis | IronMan@CerFlux.com | Study characteristics: Organoid, Drug Testing, Biomaterials, Omics, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Spheroid | Organs / tissues: Lung, Heart, Intestine / intestinal, Colon, Prostate, Breast, Tumor | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Lung Cancer, Colon Cancer, Toxicity | Cell sources: ESC, Patient-derived, Stem cell, Stem cells, Cell line, Cell lines, Epithelial cell | Cell types: Epithelial cell, Immune cell, T cell | Species: Human, Mouse, Rat |
| 10.1088/1758-5090/ae4ff7P01188 | 2026 | Evidence synthesis | qinx@ethz.ch | Study characteristics: Organoid, Microfluidics, Drug Testing, Biomaterials, Regulatory Language, Validation, iPSC | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Spheroid | Organs / tissues: Eye, Liver, Skin, Bone, Prostate, Tumor, Vascular | Diseases / toxicity: ALS, Cancer, Tumor, Prostate Cancer | Cell sources: iPSC, ESC, Stem cell, Stem cells, Cell line, Cell lines, Endothelial cell | Cell types: Endothelial cell, T cell | Species: Human, Rat, Pig |
| 10.2147/ijn.s480168P01204 | 2026 | Review | ilaria.rea@na.isasi.cnr.it | Study characteristics: Organoid, Microfluidics, Biomaterials, Sensors, Omics, Ai, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, MPS | Organs / tissues: Liver, Intestine / intestinal, Colon, Tumor | Diseases / toxicity: ALS, Cancer, Tumor, Colon Cancer, Toxicity | Cell sources: ESC, Stem cell, Stem cells, Cell line, Cell lines, Fibroblast, Epithelial cell | Cell types: Fibroblast, Epithelial cell, T cell, Macrophage | Species: Human, Mouse, Rat |
| 10.1080/19490976.2021.1902719P01212 | 2026 | Original | liukexuan705@163.com | Study characteristics: Organoid, Microfluidics, Biomaterials, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, MPS | Organs / tissues: Brain, Lung, Heart, Cardiac, Liver, Liver / hepatic, Kidney | Diseases / toxicity: ALS, Cancer, Tumor, Infection, Diabetes, Steatosis, Crohn disease | Cell sources: ESC, Stem cell, Cell line, Epithelial cell | Cell types: Epithelial cell, Goblet Cell, T cell | Species: Human, Mouse, Rat, Dog |
| 10.1093/function/zqaf037P01221 | 2026 | Evidence synthesis | lijing@wbgcas.cn | Study characteristics: Organoid, Sensors, Regulatory Language | Quantitative reporting: Sample size / replicates | Model systems: Organoid, MPS | Organs / tissues: Brain, Eye, Lung, Heart, Cardiac, Liver, Kidney | Diseases / toxicity: ALS, COVID-19, Sars Cov, Fibrosis, Diabetes, Inflammatory bowel disease, IBD | Cell sources: ESC, Stem cell, Stem cells, Cell line, Cell lines, Genetically Engineered, Epithelial cell | Cell types: Endothelial cell, Vascular endothelial cell, Epithelial cell, Microglia, Neuron, Intestinal Stem Cell, Goblet Cell | Species: Human, Mouse, Rat, Pig |
| 10.3390/ijms22052607P01253 | 2026 | Review | michalitsa.diakatou@inserm.fr | Study characteristics: Organoid, Biomaterials, Sensors, Omics, Regulatory Language, Validation, iPSC | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid | Organs / tissues: Neural, Retina, Eye, Liver, Kidney, Gut, Colon | Diseases / toxicity: ALS, Cancer, Prostate Cancer | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Stem cell, Stem cells, Cell line, Cell lines | Cell types: Fibroblast, T cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.3389/fendo.2021.627819P01262 | 2026 | Evidence synthesis | e.voest@nki.nl | Study characteristics: Organoid, Drug Testing, Biomaterials, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid | Organs / tissues: Lung, Airway, Liver, Intestine / intestinal, Colon, Pancreas, Prostate | Diseases / toxicity: ALS, Cancer, Tumor, Lung Cancer, Pancreatic Cancer, Prostate Cancer, Infection | Cell sources: ESC, Patient-derived, Stem cell, Stem cells, Cell line, Cell lines | Species: Human, Mouse, Rat, Pig | Drugs / perturbagens: Cisplatin |
| 10.1073/pnas.1209288109/-/dcsupplemental.P01264 | 2026 | Review | junhuang@psu.edu | Study characteristics: Microfluidics, Biomaterials, Omics, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration | Organs / tissues: Vascular | Diseases / toxicity: ALS | Cell sources: ESC | Cell types: Neuron, T cell | Species: Rat, Dog | Biomaterials / ECM: PDMS |
| 10.1038/s41467-025-63955-5P01275 | 2026 | Review | horvath.peter@brc.hu | Study characteristics: Organoid, Drug Testing, Biomaterials, Sensors, Omics, Ai, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid, Spheroid, Assembloid, Tumoroid, MPS | Organs / tissues: Eye, Liver, Breast, Tumor, Vascular, Immune | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Toxicity | Cell sources: ESC, Stem cell, Cell line, Cell lines, Endothelial cell, Mesenchymal stem cell | Cell types: Endothelial cell, T cell | Species: Human, Rat |
| 10.1186/s12938-025-01476-4P01283 | 2026 | Review | stephanie.amaral@unesp.br | Study characteristics: Organoid, Microfluidics, Drug Testing, Biomaterials, Sensors, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration | Model systems: Organoid, Spheroid, MPS | Organs / tissues: Neural, Eye, Lung, Liver, Skin, Bone, Cartilage | Diseases / toxicity: ALS, Cancer, Tumor, Lung Cancer, Toxicity | Cell sources: iPSC, ESC, Patient-derived, Stem cell, Stem cells, Cell line, Cell lines | Cell types: Hepatocyte, Endothelial cell, Pericyte, Fibroblast, Immune cell, T cell, Macrophage | Species: Human, Rat, Pig |
| 10.1186/s12916-022-02688-4P01287 | 2026 | Evidence synthesis | j.fu@umcg.nl | Study characteristics: Organ-on-chip, Sensors, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organ-on-chip, MPS | Organs / tissues: Brain, Cerebral, Neural, Heart, Liver, Liver / hepatic, Kidney | Diseases / toxicity: ALS, Tumor, Diabetes, Inflammatory bowel disease | Cell sources: ESC, Fibroblast | Cell types: Fibroblast, Immune cell, T cell | Species: Human, Mouse, Rat |
| 10.1016/j.jhep.2024.12.038P01307 | 2026 | Original | xuwzhang5127@hust.edu.cn | Study characteristics: Organoid, Sensors, Omics, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, MPS | Organs / tissues: Brain, Neural, Lung, Heart, Liver, Liver / hepatic, Kidney | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Toxicity | Cell sources: ESC, Stem cell, Stem cells, Cell line, Cell lines, Crispr, Genetically Engineered | Cell types: Hepatocyte, Endothelial cell, Neuron, T cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.1053/j.gastro.2024.06.032P01316 | 2026 | Review | c.guenther@uk-erlangen.de | Study characteristics: Organoid, Biomaterials, Omics, Ai, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density, Flow rate | Model systems: Organoid | Organs / tissues: Eye, Liver, Liver / hepatic, Gut, Intestine, Intestine / intestinal, Colon | Diseases / toxicity: ALS, Cancer, Tumor, Infection, Fibrosis, IBD, Crohn disease | Cell sources: ESC, Patient-derived, Stem cell, Stem cells, Cell line, Epithelial cell, Endothelial cell | Cell types: Hepatocyte, Cholangiocyte, Endothelial cell, Epithelial cell, Paneth Cell, Immune cell, T cell | Species: Human, Mouse, Rat, Dog |
| 10.22074/cellj.2024.2023118.1510P01317 | 2026 | Evidence synthesis | alirajabi@sums.ac.ir | Study characteristics: Organoid, Microfluidics, Drug Testing, Biomaterials, Sensors, Omics, Regulatory Language | Model systems: Organoid, Spheroid, MPS | Organs / tissues: Brain, Neural, Lung, Airway, Heart, Cardiac, Liver | Diseases / toxicity: ALS, Cancer, Tumor, Fibrosis, Toxicity | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Primary cell, Primary cells, Stem cell | Cell types: Fibroblast, T cell | Species: Human, Mouse, Rat, Pig | Biomaterials / ECM: Collagen, Fibrin, Alginate, Hyaluronic Acid, Fibronectin, Hydrogel, Scaffold |
| 10.1007/s00604-026-08100-9P01318 | 2026 | Review | marta.pacheco@uah.es | Study characteristics: Organ-on-chip, Microfluidics, Sensors, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, TEER value | Model systems: Organ-on-chip, MPS | Organs / tissues: Brain, Neural, Gut, Bone | Diseases / toxicity: Alzheimer, ALS | Cell sources: ESC | Cell types: Microglia, Neuron, T cell | Species: Human, Rat |
| 10.1186/s12879-019-4207-9P01330 | 2026 | Review | sdn@dadlnet.dk | Study characteristics: Regulatory Language, Validation | Quantitative reporting: Time / exposure duration, Sample size / replicates, Shear stress | Organs / tissues: Lung, Heart, Cardiac, Liver, Kidney, Pancreas, Immune | Diseases / toxicity: ALS, Cancer, Infection | Cell sources: ESC | Cell types: Immune cell, T cell, NK cell | Species: Human, Rat | Media: MEM |
| 10.1038/s41587-021-00960-1P01332 | 2026 | Original | — | Study characteristics: Organoid, Regulatory Language | Model systems: Organoid | Organs / tissues: Eye, Heart, Gut | Species: Human | Regulatory: EMA, ICH | Supplements: ITS |
| 10.1093/nar/gkx995P01335 | 2026 | Original | philipp.bucher@epfl.ch | Study characteristics: Regulatory Language | Quantitative reporting: Sample size / replicates | Organs / tissues: Eye | Diseases / toxicity: ALS, Cancer | Cell sources: ESC, Cell line | Species: Human, Mouse, Rat, Pig | Biomaterials / ECM: BME | Media: MEM |
| 10.1186/s12943-026-02611-yP01358 | 2026 | Review | jmerchant@arizona.edu | Study characteristics: Organoid, Biomaterials, Sensors, Omics, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Tumoroid | Organs / tissues: Brain, Neural, Eye, Lung, Liver, Kidney / renal, Gut | Diseases / toxicity: ALS, Glioblastoma, Cancer, Tumor, Pancreatic Cancer | Cell sources: ESC, Primary cell, Patient-derived, Stem cell, Stem cells, Cell line, Cell lines | Cell types: Astrocyte, Neuron, T cell | Species: Human, Mouse, Rat, Pig, Dog |
| 10.1128/aac.01482-25P01360 | 2026 | Evidence synthesis | kasem.kuk@mahidol.ac.th | Study characteristics: Organoid, Organ-on-chip, Drug Testing, Omics, Regulatory Language, Validation, iPSC | Quantitative reporting: Concentration, Time / exposure duration, Seeding density | Model systems: Organoid, Organ-on-chip, MPS | Organs / tissues: Brain, Cerebral, Neural, Eye, Lung, Heart, Liver | Diseases / toxicity: ALS, Cancer, COVID-19, Infection, Toxicity | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Stem cell, Stem cells, Cell line, Cell lines | Cell types: Epithelial cell, Neuron, Immune cell, T cell, Macrophage | Species: Human, Mouse, Rat, Dog, Monkey |
| 10.1038/s42003-026-09589-9P01362 | 2026 | Review | yikeuchi@iis.u-tokyo.ac.jp | Study characteristics: Organoid, Microfluidics, Biomaterials, Sensors, Regulatory Language, iPSC, Multi Organ | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid, Spheroid, Assembloid | Organs / tissues: Brain, Cerebral, Neural, Retina | Diseases / toxicity: Alzheimer, ALS, Infection | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Stem cell, Cell line, Cell lines, hESC | Cell types: Astrocyte, Neuron, T cell | Species: Human, Mouse, Rat |
| 10.1186/s13046-026-03695-6P01371 | 2026 | Evidence synthesis | khanh.le-thi@inserm.fr | Study characteristics: Organoid, Biomaterials, Omics, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid | Organs / tissues: Eye, Liver, Kidney, Colon, Testis, Prostate, Breast | Diseases / toxicity: ALS, Cancer, Tumor, Colon Cancer, Prostate Cancer, Toxicity | Cell sources: ESC, Patient-derived, Cell line, Cell lines, Epithelial cell | Cell types: Epithelial cell, T cell | Species: Human, Mouse, Rat, Dog |
| 10.5281/zenodo.3572870.P01372 | 2026 | Original | bwdavies@austin.utexas.edu | Study characteristics: Sensors, Omics, Regulatory Language, Validation | Quantitative reporting: Sample size / replicates | Organs / tissues: Eye, Gut, Intestine, Intestine / intestinal, Colon, Skin, Breast | Diseases / toxicity: ALS, Cancer, Breast Cancer, Infection, NASH | Cell sources: ESC | Species: Human, Rat | Chip materials: COC | Sensors: Sensor |
| 10.64898/2026.02.16.700850;P01375 | 2026 | Evidence synthesis | LNONN@UIC.EDU | Study characteristics: Organoid, Drug Testing, Biomaterials, Omics, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid, Spheroid, MPS | Organs / tissues: Heart, Cardiac, Kidney, Colon, Skin, Bone, Prostate | Diseases / toxicity: ALS, Cancer, Tumor, Prostate Cancer | Cell sources: ESC, Patient-derived, Stem cell, Stem cells, Cell line, Cell lines, Genetically Engineered | Cell types: Endothelial cell, Pericyte, Fibroblast, Epithelial cell, T cell, B cell, Macrophage | Species: Human, Mouse, Rat |
| 10.1038/s41598-026-42089-8P01383 | 2026 | Original | k.eastlake@ucl.ac.uk | Study characteristics: Organoid, Microfluidics, Biomaterials, Sensors, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid, MPS | Organs / tissues: Brain, Neural, Retina, Eye, Liver, Kidney / renal, Bone | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Prostate Cancer, Toxicity | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Embryonic Stem Cell, Stem cell, Stem cells, Cell line | Cell types: Fibroblast, Epithelial cell, Neuron, T cell | Species: Human, Mouse, Rat, Zebrafish, Pig |
| 10.3389/fcell.2026.1777400P01390 | 2026 | Evidence synthesis | — | Study characteristics: Organoid, Organ-on-chip, Microfluidics, Drug Testing, Biomaterials, Omics, Ai | Quantitative reporting: Sample size / replicates | Model systems: Organoid, Spheroid, Organ-on-chip | Organs / tissues: Eye, Lung, Liver, Liver / hepatic, Gut, Intestine, Intestine / intestinal | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Colon Cancer, Prostate Cancer, Inflammatory bowel disease | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Patient-derived, Adult stem cell, Stem cell, Stem cells | Cell types: Fibroblast, Immune cell, T cell, Macrophage | Species: Human, Mouse, Rat, Pig, Dog |
| 10.1158/0008-5472.can-24-4165P01409 | 2026 | Review | frederic.lluisvinas@kuleuven.be | Study characteristics: Organoid, Drug Testing, Biomaterials, Omics, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid | Organs / tissues: Eye, Gut, Colon, Prostate, Breast, Tumor, Immune | Diseases / toxicity: ALS, Glioblastoma, Cancer, Tumor, Breast Cancer, Pancreatic Cancer, Prostate Cancer | Cell sources: ESC, Embryonic Stem Cell, Patient-derived, Stem cell, Stem cells, Cell line, Cell lines | Cell types: T cell | Species: Human, Mouse, Rat |
| 10.1088/1758-5090/ae5347P01423 | 2026 | Review | kcsmith@illinois.edu | Study characteristics: Organoid, Microfluidics, Drug Testing, Biomaterials, Sensors, Omics, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, Spheroid | Organs / tissues: Liver / hepatic, Colon, Pancreas, Bone, Muscle, Breast, Tumor | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Colon Cancer, Pancreatic Cancer, Leukemia | Cell sources: ESC, Patient-derived, Cell line, Cell lines, Fibroblast, Epithelial cell | Cell types: Fibroblast, Epithelial cell, Neuron, Immune cell, T cell | Species: Human, Rat |
| 10.1128/mbioP01433 | 2026 | Evidence synthesis | melinda.engevik@bcm.edu | Study characteristics: Organoid, Biomaterials, Sensors, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid | Organs / tissues: Brain, Eye, Heart, Liver, Gut, Intestine, Intestine / intestinal | Diseases / toxicity: ALS, Cancer, Tumor, Colon Cancer, Infection, NASH, IBD | Cell sources: ESC, Stem cell, Stem cells, Cell line, Cell lines, Epithelial cell, MSC | Cell types: Epithelial cell, Goblet Cell, Immune cell, T cell, Macrophage | Species: Human, Mouse, Rat |
| 10.1088/1758-5090/ae40a0P01440 | 2026 | Review | bernhard.wolfrum@tum.de | Study characteristics: Organoid, Microfluidics, Drug Testing, Biomaterials, Sensors, Omics, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Shear stress, Oxygen concentration | Model systems: Organoid, Spheroid, Assembloid | Organs / tissues: Brain, Cerebral, Neural, Eye, Cardiac, Colon, Skin | Diseases / toxicity: Alzheimer, Parkinson, ALS | Cell sources: iPSC, Induced Pluripotent Stem Cell, ESC, Patient-derived, Stem cell, Stem cells, Endothelial cell | Cell types: Cardiomyocyte, Endothelial cell, Neuron, T cell | Species: Human, Mouse, Rat |
| 10.1021/acsnano.5c03799P01446 | 2026 | Review | algarfe4@etsia.upv.es | Study characteristics: Organoid, Microfluidics, Biomaterials, Sensors, Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid, Spheroid, MPS | Organs / tissues: Brain, Eye, Lung, Heart, Liver, Kidney, Intestine / intestinal | Diseases / toxicity: ALS, Glioblastoma, Cancer, Tumor, Breast Cancer, Lung Cancer, Colon Cancer | Cell sources: ESC, Patient-derived, Cell line, Cell lines, Fibroblast | Cell types: Fibroblast, Immune cell, T cell, Dendritic Cell | Species: Human, Mouse, Rat, Dog |
| 10.1093/procel/pwag011P01453 | 2026 | Evidence synthesis | openaccess.library@eur.nl | Study characteristics: Organoid, Microfluidics, Ai, Regulatory Language, Validation, iPSC | Quantitative reporting: Time / exposure duration | Model systems: Organoid, MPS | Organs / tissues: Brain, Cardiac, Liver, Liver / hepatic, Kidney, Kidney / renal, Gut | Diseases / toxicity: ALS, Tumor, Fibrosis, Steatosis | Cell sources: Induced Pluripotent Stem Cell, ESC, Stem cell, Stem cells, Fibroblast, Epithelial cell | Cell types: Hepatocyte, Cholangiocyte, Fibroblast, Epithelial cell, Astrocyte, Neuron, T cell | Species: Human, Mouse, Rat, Pig |
| 10.1128/msphere.01136-20.P01455 | 2026 | Evidence synthesis | mestes@bcm.edu | Study characteristics: Organoid, Biomaterials, Omics, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid | Organs / tissues: Gut, Intestine, Intestine / intestinal, Colon | Diseases / toxicity: ALS, Cancer, Infection | Cell sources: ESC, Stem cell, Cell line, Cell lines, Epithelial cell | Cell types: Epithelial cell, Intestinal Stem Cell, Enterocyte, Goblet Cell, T cell | Species: Human, Rat, Pig |
| 10.1128/msphere.00448-24P01456 | 2026 | Review | mestes@bcm.edu | Study characteristics: Organoid, Omics, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: Organoid, MPS | Organs / tissues: Eye, Liver, Kidney, Gut, Intestine, Intestine / intestinal, Colon | Diseases / toxicity: ALS, Cancer, Infection, Diabetes, NASH | Cell sources: ESC, Embryonic Stem Cell, Patient-derived, Stem cell, Stem cells, Cell line, Genetically Engineered | Cell types: Epithelial cell, Neuron, Intestinal Stem Cell, Immune cell, T cell, B cell | Species: Human, Mouse, Rat, Zebrafish |
| 10.1186/s13072-025-00652-zP01464 | 2026 | Original | vorobyeva@genebiology.ru | Study characteristics: Sensors, Omics, Regulatory Language | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates | Model systems: MPS | Organs / tissues: Neural, Heart, Gut, Ovary, Breast, Tumor | Diseases / toxicity: ALS, Cancer, Tumor, Breast Cancer, Infection | Cell sources: ESC, Cell line, Cell lines | Cell types: T cell, Macrophage | Species: Human, Rat, Pig |
| 10.1128/aemP01479 | 2026 | Original | wangzh@fafu.edu.cn | Study characteristics: Omics, Regulatory Language, Validation | Quantitative reporting: Concentration, Time / exposure duration | Organs / tissues: Retina, Gut, Colon, BBB | Diseases / toxicity: ALS, Infection, IBD | Cell sources: ESC | Cell types: T cell | Species: Human, Rat, Pig, Dog | Media: MEM |
| 10.1038/s42003-026-09770-0P01496 | 2026 | Review | fengyukuan@tjmuch.com | Study characteristics: Organoid, Biomaterials, Omics, Ai, Regulatory Language, Validation, Patient-derived | Quantitative reporting: Concentration, Time / exposure duration, Sample size / replicates, Seeding density | Model systems: Organoid | Organs / tissues: Brain, Retina, Eye, Lung, Heart, Liver, Colon | Diseases / toxicity: ALS, Cancer, Tumor, Lung Cancer, Pancreatic Cancer, Leukemia, Infection | Cell sources: ESC, Patient-derived, Cell line, Cell lines, Crispr | Cell types: T cell, Macrophage | Species: Human, Mouse, Rat, Dog |
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