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Registration OpenDecember 1-2, 2026Charlotte, North Carolina11th Annual Regenerative Manufacturing Innovation Consortium (RegMIC) Meeting
About RegMICRegMIC 2026 DetailsRegister
Methodology

Toward Standardization

Lung Fidelity Benchmark

Compare lung epithelial culture models with a fixed healthy human distal lung tissue reference. The benchmark reports transcriptomic proximity using PCA centroid distance, Spearman correlation, and robustness summaries across PCA preprocessing choices.

Reference anchorGSE165192-Human healthy distal lung tissue
PCA centroid distanceLower distance means closer global transcriptomic proximity
Spearman correlationHigher correlation means stronger gene-level rank similarity
Dolan-Moré profileTests whether ranking stays stable across 32 PCA preprocessing choices

User data format

Upload healthy, mock, untreated, or baseline lung epithelial culture RNA-seq data

Use CSV files where rows are genes and columns are samples. The first column must be named exactly Gene Symbol. Values should be raw counts or count-like non-negative expression values. Already z-scored or already batch-corrected values should not be used.

Gene SymbolSample_1Sample_2Sample_3
TP53120135141
EPCAM500490510
KRT8850870860

Demo database

Run the built-in lung culture fidelity benchmark

The demo compares public lung epithelial culture systems against the fixed healthy human distal lung tissue reference. It includes primary monolayers, immortalized monolayers, ALI-differentiated epithelium, bronchial organoids, and engineered airway organ tissue equivalents.

GSE165192-HumanHealthy human distal lung tissue reference
NHBE / hBEpCPrimary epithelial monolayer baselines
A549 / A549-ACE2 / Calu-3Immortalized or epithelial monolayer models
ALI-HBECsDifferentiated polarized airway epithelium
hBO3D bronchial organoid model
OTEEngineered airway organ tissue equivalent
Ready.

Manufacturing partner

RegMIC

Connect with RegMIC and its work advancing regenerative manufacturing, scale-up, and commercialization across the PhysioVerse ecosystem.

About RegMIC

The Regenerative Manufacturing Innovation Consortium (RegMIC), founded in 2014, is a national initiative that brings together stakeholders from industry, academia, and government to advance the manufacturing, scale-up, and commercialization of regenerative technologies. Through cross-sector collaboration, RegMIC addresses key challenges in translation, including process development, regulatory alignment, and the establishment of best practices across cell, tissue, and advanced in vitro systems.